History and Biology of Erythropoietin in Hematopoietic and Non-Neural Tissues
Erythropoietin and the Nervous System(2006)
Abstract
Erythropoietin (EPO) is a glycoprotein hormone, which is produced in kidney and liver, and is mainly involved in regulating
proliferation and maturation of red blood cells. EPO gene expression is induced by hypoxia through the transcription factor
hypoxia inducible factor-1, which has been found to be the main regulator of oxygen homeostasis in the body. Suppression of
apoptosis is the principle mechanism of action of EPO in maintaining erythropoiesis. It has been recently recognized that
EPO is a member of the cytokine type I superfamily and it has multiple effects in organs and tissues different from the hematopoietic
system. Recent evidence of EPO as a protective factor in various injury models in the nervous system and heart has raised
the possibility that EPO can exert protective effects in many organs in the body. However, whether the mechanism of protective
action involves inhibition of apoptosis remains to be seen.
MoreTranslated text
Key words
and tissue-protection,history,hypoxia inducible factor-1,apoptosis,erythropoietin,erythropoiesis
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined