Effect of Interferon-γ on the CXC Ligand 16 Expression and the Lipid Accumulation in the Rat Aortic Smooth Muscle Cells
Chinese Journal of Arteriosclerosis(2008)
摘要
Aim To investigate whether CXC ligand 16(CXCL16) expressions were controlled by interferon-gamma(IFN-γ) secreted by the activated T cells and the effect on lipid accumulation in the rat aortic smooth muscle cells(SMC). Methods The cells were grown to confluence and then incubated with different concentration of IFN-γ.The CXCL16 expression was identified by reverse transcription polymerase chain reaction(RT-PCR);The effect of IFN-γ on oxidized low density lipoprotein(ox-LDL) uptake was identified by high performance liquid chromatography(HPLC) analysis. Results The CXCL16 mRNA expression was significantly increased after IFN-γ treatment;The rat aortic SMC lipid accumulation after IFN-γ treatment was increased in treated cells compared with untreated cells. Conclusion The T cell cytokine IFN-γ induces CXCL16 mRNA expression in rat aortic SMC and then leads to lipid accumulation in rat aortic SMC.
更多查看译文
关键词
CXC Ligand 16,Atherosclerosis,Interferon-Gamma,Lipid Accumulation,Oxidize Low Density Lipoprotein
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要