(18)F-FDG PET/CT imaging and diagnosis method of pancreatic carcinoma

Objective To explore the value of 18F-FDG PET/CT in the diagnosis of pancreatic carcinoma,and to analyze the method of diagnosis.Methods 18F-FDG PET/CT was performed in 88 patients with primary pancreatic lesions(65 malignant,23 benign).The visual assessment and semiquantitative analysis were used to analyze the lesions' PET/CT characteristics.A 5-point rank scale was used for visual assessment according to the CT features,the degree of 18F-FDG uptake and the PET/CT characteristics.The maximum standardized uptake value(SUV_max) was measured for semiquantitative analysis.Results The sensitivity,specificity,accuracy with visual assessment was 92.31%(60/65),69.57%(16/23),86.36%(76/88) for CT;90.77%(59/65),78.26%(18/23),87.50%(77/88) for PET visual analysis;98.46%(64/65),91.30%(21/23),96.59%(85/88) for PET/CT visual analysis.The areas under the receiver operating characteristics curves(ROC-AUC) were all more than 0.90.The average value of SUV_max for malignant lesions(8.06±2.96) was statistically different from benign lesions(3.13±2.09,t=7.344,P0.01),but no statistical difference was found between peripancreatic tissue invasion or metastasis group(8.06±3.01) and primary pancreatic carcinoma group(7.23±2.96,t=0.693,P=0.381).With a threshold of 4.65,SUV_max showed a sensitivity of 87.69% and a specificity of 86.96% in differentiating malignant lesions from benign lesions.Conclusion 18F-FDG PET/CT has important value in the diagnosis of pancreatic malignant tumor,and the 5-point rank scale-visual assessment of PET/CT is an excellent method in differentiating malignant pancreatic lesions from benign lesions.