The discovery of glycine and related amino acid-based factor Xa inhibitors.
Bioorganic & medicinal chemistry(2006)
Abstract
Herein, we report on the identification of three potent glycine and related amino acid-based series of FXa inhibitors containing a neutral P1 chlorophenyl pharmacophore. A X-ray crystal structure has shown that constrained glycine derivatives with optimized N-substitution can greatly increase hydrophobic interactions in the FXa active site. Also, the substitution of a pyridone ring for a phenylsulfone ring in the P4 sidechain resulted in an inhibitor with enhanced oral bioavailability.
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Key words
factor Xa inhibitor,antithrombotics
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