CCR5 receptor antagonists: discovery and SAR of novel 4-hydroxypiperidine derivatives.
Bioorganic & Medicinal Chemistry Letters(2007)
Abstract
Optimizing the guanylhydrazone of 2-(4-chlorobenzyloxy)-5-bromobenzaldehyde, which is a hit from high-throughput screening (HTS), let to discover the potent 4-hydroxypiperidine derivatives as a CCR5 receptor antagonist.
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Key words
CCR5 receptor antagonists,Hydroxypiperidine,Chemokine
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