Structure and property based design of factor Xa inhibitors: Pyrrolidin-2-ones with aminoindane and phenylpyrrolidine P4 motifs

Bioorganic & Medicinal Chemistry Letters(2011)

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摘要
The discovery of potent series of orally available factor Xa inhibitors with aminoindane and phenylpyrrolidine motifs is described.
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关键词
Factor Xa,Oral inhibitors,Property based design,Structure based design,P450 inhibition
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