Non-hinge-binding pyrazolo[1,5-a]pyrimidines as potent B-Raf kinase inhibitors
Bioorganic & Medicinal Chemistry Letters（2010）
Abstract
Optimization of initial lead compound 1 provided a series of pyrazolo[1,5-a]pyrimidines 2 as potent B-Raf kinase inhibitors.
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Key words
Raf,Kinase,Inhibitor,Pyrazolo[1,5-a]pyrimidine
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