Triggering antiviral response by RIG-I-related RNA helicases.
Biochimie(2007)
Abstract
TLRs detect several classes of virus-associated molecules, such as ssRNA, CpG-DNA and dsRNA, and transduce signals leading to the production of IFN. Recently discovered cytoplasmic RNA helicases, RIG-I and MDA5, selectively sense viral RNA species. Gene disruption studies revealed the critical but non-redundant function of RIG-I and MDA5 in host antiviral responses.
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Key words
Interferon,RNA helicase,Innate immunity,TLR,Double-stranded RNA
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