Novel benzofuran derivatives with dual 5-HT1A receptor and serotonin transporter affinity

Aranapakam M. Venkatesan,O. Dos Santos,John Ellingboe,Deborah A. Evrard,Boyd L. Harrison,Deborah L. Smith,Rosemary Scerni,Geoffrey A. Hornby,Lee E. Schechter,Terrence H. Andree

Bioorganic & Medicinal Chemistry Letters（2010）

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摘要

Several benzofuran derivatives linked to a 3-indoletetrahydropyridine through an alkyl chain were prepared and evaluated for serotonin transporter and 5-HT1A receptor affinities. Their design, synthesis and structure–activity relationships are described.

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关键词

SSRI,5HT-1A,Benzofuran

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