The Spiroketals Containing A Benzyloxymethyl Moiety At C8 Position Showed The Most Potent Apoptosis-Inducing Activity.

S Mitsuhashi,H Shima,T Kawamura,K Kikuchi,M Oikawa,A Ichihara,H Oikawa

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（1999）

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摘要

The spiroketals containing a benzyloxymethyl moiety at the C8 position showed the most potent apoptosis-inducing activity, whereas its analogous compounds lacking any substituent at C8 or possessing ones other than the benzyloxymethyl moiety at C8 were all much less active, These results strongly suggest an important role of the benzyloxymethyl moiety linked to the C8 oxygen atom. (C) 1999 Elsevier Science Ltd. All rights reserved.

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spiroketals,benzyloxymethyl moiety,apoptosis-inducing

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