Innovative tissue engineering structures through advanced manufacturing technologies

Journal of materials science. Materials in medicine(2004)

Cited 42|Views9
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Abstract
A wide range of rapid prototyping (RP) techniques for the construction of three-dimensional (3-D) scaffolds for tissue engineering has been recently developed. In this study, we report and compare two methods for the fabrication of poly-(ε-caprolactone) and poly- (ε-caprolactone)–poly-(oxyethylene)–poly-(ε-caprolactone) copolymer scaffolds. The first technique is based on the use of a microsyringe and a computer-controlled three-axis micropositioner, which regulates motor speed and position. Polymer solutions are extruded through the needle of the microsyringe by the application of a constant pressure of 10–300 mm Hg, resulting in controlled polymer deposition of 5–600 μm lateral dimensions. The second method utilises the heating energy of a laser beam to sinter polymer microparticles according to computer-guided geometries. Materials may be fed either as dry powder or slurry of microparticles. Both powder granulometry and laser working parameters influence resolution (generally 300 μm×700 μm), accuracy of sintering and surface and bulk properties of the final structures. The two RP methods allow the fabrication of 3-D scaffolds with a controlled architecture, providing a powerful means to study cell response to an environment similar to that found in vivo.
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Key words
Tissue Engineering,Rapid Prototype,Advanced Manufacturing,Motor Speed,Oxyethylene
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