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Conformationally Constrained Farnesoid X Receptor (FXR) Agonists: Heteroaryl Replacements of the Naphthalene.

Jonathan Y. Bass,Justin A. Caravella,Lihong Chen,Katrina L. Creech,David N. Deaton,Kevin P. Madauss,Harry B. Marr,Robert B. McFadyen,Aaron B. Miller,Wendy Y. Mills,Frank Navas,Derek J. Parks,Terrence L. Smalley,Paul K. Spearing,Dan Todd,Shawn P. Williams,G. Bruce Wisely

Bioorganic & Medicinal Chemistry Letters（2010）

Cited 60|Views63
Key words
Farnesoid X receptor,FXR,Nuclear receptor modulator,FXR X-ray co-crystal structure,GW 4064,GSK8062,Bile acid receptor,NR1H4 GSK2324
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