In-Vitro Activity Of Recombinant Lysostaphin Antibiotic Combinations Toward Methicillin-Resistant Staphylococcus-Aureus
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE(1993)
摘要
In vitro bactericidal experiments were performed with combinations of recombinant lysostaphin and various antibiotics against five strains of Staphylococcus aureus, including clinical isolates of methicillin-resistant S. aureus (MRSA). Sublethal concentrations of lysostaphin combined with beta-lactam antibiotics (including benzylpenicillin, methicillin, and cephalosporin B), bacitracin, or polymyxin B, exhibited rapid synergistic bactericidal activity against all S. aureus strains tested. Lysostaphin activity was additive when combined with either vancomycin, gentamicin, tetracycline, or erythromycin. Synergistic combinations of recombinant lysostaphin and antibiotics might be applicable to controlling cutaneous staphylococcal infections anti MRSA carriage.
更多查看译文
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要