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Synthesis of stereoisomers of 1,4:3,6-dianhydrohexitol nitrate derivative, KF-14124

Hiroaki Hayashi,Hideo Ueno,Fumio Suzuki

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（1992）

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Abstract
All of the three stereoisomers of 5-deoxy-5-[4-(3-phenylthiopropyl)piperazin-1-yl]-1,4:3,6-dianhydro-L-iditol 2-nitrate (KF-14124; 4) were synthesized from a common key intermediate (8).
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Hydrophilic Interaction Chromatography (HILIC)
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