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INTERLEUKIN-10 SERUM LEVELS ARE LOWER IN SUSTAINED VIROLOGICAL RESPONDERS (SVR) CARRYING IL-28B CC GENOTYPE (rs12979860) COMPARED TO SVR-CT/ TT

Journal of Hepatology(2013)

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Abstract
Background and Aims: Recently, a strong association between hemoglobin decline during peginterferon alfa-2b (Peg2b)/ribavirin (RBV) treatment and increasing SVR rates of patients with HCV genotype 1 (G1) infection has been shown which most likely reflects pharmacodynamic effects of RBV.In contrast, leukocyte decline during antiviral treatment may reflect pharmacodynamic effects of pegylated interferons.We therefore investigated the possible association between leukocyte decline and SVR in patients treated with Peg2b/RBV for chronic HCV G1 infection.Methods: Data from the German Peg2b/RBV observational study were retrospectively analyzed.This real-life cohort study assessed the safety and efficacy of treatment of G1 infection with Peg2b 1.5 mg/kg/week+weight-based RBV (800-1200 mg/day) for up to 48 weeks at 285 sites.Patients who discontinued for non-response or other reasons were analyzed.SVR was defined as undetectable serum HCV-RNA 24 weeks after EOT response.Results: 1.890 patients with G1 infection (44.1±12.3years, female 43%, BMI 25.3±4.7,52.2% with high baseline viral load ≥600,000 IU/ml) had baseline and at least one leukocyte measurement during therapy.Overall sustained virologic response (SVR) following Peg2b/RBV treatment was 42.3%.When leukocytes declined during treatment by <1000/ml or by 1000-<2000/ml from baseline, poor SVR rates of only 23.2% and 33.9% were observed (Table ).In contrast, higher SVR rates up to 48.6% were achieved when leukocyte declined by 2000/ml or more.A similar but inverse correlation was observed between maximal leukocyte decline and non-response rates while relapse rates did not show any association with the decline in leukocyte counts.Table 1.Leukocyte decline (n/ml) SVR % (n/N) Non-response % (n/N) Relapse % (n/N)Conclusions: Leukocyte decline predicts SVR in patients undergoing Peg2b/RBV treatment of chronic HCV G1 infection.The magnitude of leukocyte decline as pharmacodynamic Peg2b effect seems in part reflect its antiviral activity.
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Key words
sustained virological responders,cc genotype
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