Design, new synthesis, and calcilytic activity of substituted 3H-pyrimidin-4-ones

Irina Shcherbakova,Guangfei Huang,Otto J. Geoffroy,Satheesh K. Nair,Krzysztof Swierczek,Manuel F. Balandrin,John Fox,William L. Heaton,Rebecca L. Conklin

Bioorganic & Medicinal Chemistry Letters（2005）

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摘要

Design, new synthesis, structure–activity relationship studies and calcium receptor antagonist (calcilytic) properties of novel 3H-pyrimidin-4-ones are described.

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关键词

3H-Pyrimidin-4-ones,Calcium receptor antagonists,Calcilytics,Osteoporosis

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