Structural Imaging Of Drug Actions In Neurodegenerative Diseases
IMAGING IN CNS DRUG DISCOVERY AND DEVELOPMENT: IMPLICATIONS FOR DISEASE AND THERAPY(2010)
Abstract
Structural MRI (volumetric MRI and diffusion tensor imaging) provides objective and reliable measures which are highly correlated
to the neuronal loss and white matter damage observed in neurodegenerative diseases. Therefore, structural MRI is increasingly
used as a surrogate outcome marker in clinical trials assessing the effects of new treatments against neurodegenerative diseases.
This chapter provides an overview of structural MRI as a biomarker in clinical trials, its strengths and limitations, and
the techniques used in such trials and summarizes the results of treatment trials of Alzheimer’s disease and vascular impairment/dementia
using structural MRI as an outcome marker.
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