Studies on the stimulation of hemopoiesis by batyl alcohol

1. 1. The hemopoietic effects in normal rats of oral batyl alcohol consist of erythrocytosis, due to the production of microcytes, together with reticulocytosis, thrombocytosis, leukocytosis, and hyperplasia of all myeloid elements. 2. 2. The erythrocytic response is identical with that induced by the thermostable, ether-soluble plasma erythropoietic factor and is not associated with increased hemoglobin or hematocrit levels. Batyl alcohol also fails to enhance the incorporation of iron 59 in hemoglobin of recipient rats or in vitro bone marrow cultures. 3. 3. Larger amounts of batyl alcohol are required to elicit leukocytosis, which is primarily the result of a relative and absolute neutrophilia, than are needed to exert detectable erythropoietic and thrombopoietic activity. 4. 4. It is suggested that batyl alcohol or some closely related substance may play an important role in the regulatory control of hemopoiesis.