Triggering the succinate receptor GPR91 on dendritic cells enhances immunity

Tina Rubic,Günther Lametschwandtner, Sandra Jost,Sonja Hinteregger,Julia Kund,Nicole Carballido-Perrig,Christoph Schwärzler,Tobias Junt,Hans Voshol,Josef G Meingassner,Xiaohong Mao,Gudrun Werner,Antal Rot,José M Carballido

NATURE IMMUNOLOGY（2008）

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摘要

Succinate is a Krebs cycle intermediate. Carballido and colleagues show that succinate released by necrotic cells also functions as an 'alarmin' by activating dendritic cells that express the succinate receptor GPR91.

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关键词

immune system,immunologist,intracellular calcium,specific activity,proinflammatory cytokine,immunology,antigen presentation,g protein coupled receptor,innate immunity,nature,gene recombination,signaling,apoptosis,gene regulation

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