Effect of Genetic Factor on Ischemic Cerebrovascular Disease

[Objective]To investigate the effect of genetic factors on ischemic cerebrovascular disease.[Methods]Matched case-control study of genetic epidemiology was adopted to collect the prevalence status of cardiovascular and cerebrovascular disease of 157 patients' first degree relatives in proband pedigree group,as well as another 157 in control pedigree group. The risk rate and the heritability of patients with family history of ischemic cardiovascular and cerebrovascular disease were evaluated.[Results]36.94% of the ischemic cerebrovascular disease cases had family history. The number of male or female patients with family history of cardiovascular and cerebrovascular diseasess in proband group was higher than that in the control group. The incidence of cardiovascular and cerebrovascular diseases was 28.66% in the mothers of ischemic cerebrovascular disease patients,which was higher than that in the fathers of ischemic cerebrovascular disease patients (8.28%) (χ2=21.66,P0.01). The heritability of ischemic cerebrovascular disease was (53.16±4.53)%.[Conclusion]Genetic factor is a risk factor for ischemic cerebrovascular disease.