Erythropoietin expresson during the postnatal development of the rat retina

Event Abstract Back to Event Erythropoietin expresson during the postnatal development of the rat retina Arnold Szabó1*, Dora Vegvari1, Attila Magyar1, Gabor Deak2, Akos Lukats1, Agnes I. Berta1 and Agoston Szel1 1 Department of Human Morphology and Developmental Biology, Semmelweis University, Hungary 2 Eye Clinic, Semmelweis University, Hungary Both the erythropoietin (EPO) and its receptor (EPO-R) are expressed in the retina, however, their cellular distribution and involvement in retinal development is not known. In the present study, we examined developing postnatal and adult rat retinas in order to identify the temporal and spatial onset of their expression. In the adult retina both the EPO and its receptor were expressed in the photoreceptor inner segments, in the inner nuclear, ganglion, and both plexiform layers. Their expression patterns changed similarly. At birth, we found strong immunoreactivities in the ganglion cell layer and in the inner cell rows of the neuroblast layer and weak staining in the outer part of the neuroblast layer. During the following days the immunoreactivity of the ganglion cells and presumptive amacrine cells became more prominent. The cells of the ganglion cell layer showed a cytoplasmatic staining to the anti-erythropoietin antibody. From the second half of the first postnatal week strongly stained horizontal cells were observed by both antibodies at the level of the separating outer plexiform layer. During the second week a transient EPO-R expression was found in some cells of the outer nuclear layer, which followed a centroperipheral gradient. At the level of the developing photoreceptor inner and outer segments exclusively the inner segments were positively stained by both antibodies. We assume that the EPO is produced locally by the ganglion cells and its main targets are the amacrine, horizontal and photoreceptor cells and it may act as a regulating factor during the retinal development. Conference: 12th Meeting of the Hungarian Neuroscience Society, Budapest, Hungary, 22 Jan - 24 Jan, 2009. Presentation Type: Poster Presentation Topic: Developmental neurobiology and subcortical functions Citation: Szabó A, Vegvari D, Magyar A, Deak G, Lukats A, Berta AI and Szel A (2009). Erythropoietin expresson during the postnatal development of the rat retina. Front. Syst. Neurosci. Conference Abstract: 12th Meeting of the Hungarian Neuroscience Society. doi: 10.3389/conf.neuro.01.2009.04.076 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 03 Mar 2009; Published Online: 03 Mar 2009. * Correspondence: Arnold Szabó, Department of Human Morphology and Developmental Biology, Semmelweis University, Budapest, Hungary, szabar@ana2.sote.hu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Arnold Szabó Dora Vegvari Attila Magyar Gabor Deak Akos Lukats Agnes I Berta Agoston Szel Google Arnold Szabó Dora Vegvari Attila Magyar Gabor Deak Akos Lukats Agnes I Berta Agoston Szel Google Scholar Arnold Szabó Dora Vegvari Attila Magyar Gabor Deak Akos Lukats Agnes I Berta Agoston Szel PubMed Arnold Szabó Dora Vegvari Attila Magyar Gabor Deak Akos Lukats Agnes I Berta Agoston Szel Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.