S2072 Interferon-Related Autoimmune Thyroid Disease in 3414 Naïve Patients with Chronic Hepatitis C

University Hospital, were enrolled.Patients with symptoms consistent with IBS diarrhea and healthy control were included.History and physical examination was done.Stool examination was done by microscopy, culture for B hominis and polymerase chain reaction (PCR) for B. hominis and its typing was also done.DNA extraction from stool culture was done with stool DNA extraction kit (Qiagen).Primers used for PCR were previously described.Two sided Fischer-exact test was used to determine the statistical significance.Results: There were thirty-three patents with mean age 43±17.2,age range 16-75 years and male; female ratio of 24:9.Patients with IBS-diarrhea were 27(82%) and healthy control 6(18%).Twentyone (64%) had infection with a single type of B hominis, 6(18%) had mixed type while 6(18%) were not typeable.Infection with B hominis type 1 was seen in 13(39%), type 3 in 8(24%) and mixed type in 6(18%).Of twenty-three patients with IBS-diarrhea 17(74%) had infection with single type of B hominis while 6(26%) with mixed types as compared with control 4(100%) having single type of B hominis p= 0.54.Conclusion: Patients with IBS-diarrhea had infection with single genotype of B hominis, predominantly type 1.However, these are the preliminary results of an ongoing study. S2069Lactose and Fructose Malabsorption in Patients with Functional Bowel Disorders Clive H. Wilder-Smith, Jonathan Schuler Sugar malabsorption can result in gastrointestinal symptoms similar to functional bowel disorders (FBD).Both occur commonly and there appears to be considerable overlap between either lactose or fructose malabsorption and IBS, and the latter may improve with sugar restriction.The coincidence of fructose and lactose malabsorption is uncertain in FBD and this differential diagnosis and the corresponding therapeutic options are often overlooked.Lactose and fructose malabsorption were tested by standardized H2 and CH4 breath testing with symptom scoring in a single center in 255 successive primary and secondary care patients (mean±SD age 42±17yr, 181 females, 98% Caucasian) with FBD.Fructose or lactose malabsorption were demonstrated in 62% and 32% of patients, respectively, and both tests were positive in 22% and both were negative in 25% of patients based on H2 (>20ppm) and CH4 (>8ppm) thresholds.Mean peak H2 and CH4 concentrations of positive tests were 61±39ppm (range 21-226) and 21±13ppm (9-38) after fructose, and 73±45ppm (21-382) and 68±51ppm (9-180) after lactose, respectively.Overall, CH4 analysis increased the number of positive tests by 20% compared to only H2 testing.Symptom scoring and gas threshold analysis were concordant in 82% of fructose and in 89% of lactose tests.All patients with positive tests were placed on the appropriate low sugar diet(s).In this large cohort fructose malabsorption was more common in FBD than lactose malabsorption, but both coexisted in a significant proportion of patients.