[760] ROSIGLITAZONE DOES NOT IMPROVE NASH LESION IN ob/ob MICE

S285Pre transplant: 37% living alone, 58% unemployed, 38% spent most time in the community; while 20% were predominantly in patients.Average alcohol use was 192 units/week.Average duration of abstinence prior to LT was 18 months; 29% had undergone some form of alcohol aversion therapy;.48% had history of alcohol dependence in first degree relatives; 20% had psychological disease.Post transplant: mean follow up 59 months, average duration for abstinence 33 months; 33 reported some alcohol use post LT; average consumption 7.8 unitsiweek.Pattern of drinking classified as none, occasional, regular and harmful was 53%, 19%, 15%, and 13% respectively: of these 23% underwent treatment.5% refused treatment.72%no treatment.8% had new diagnosis of psychological disease, 20% required hospital admission regarding alcohol use.Pretransplant variables of age, marital status, employment, period of abstinence, treatment for alcoholism pretransplant, family history of alcoholism, psychiatric history did not predict abstinence post LT (p > 0.05).Univariately prediction of drinking post LT was whether patients were abstinent at home or hospital bound, and family history of alcohol abuse (p = 0.005, 0.013 respectively).Conclusions: Even in a carefully analysed group of patients, it is hard to identify factors that reliably predict abstinence post LT.Patients who are abstinent because they are "too sick to drink are more at risk of relapse.The context of abstinence needs to be considered.