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In vitro oxidation of MPTP by primate neural tissue: A potential model of MPTP neurotoxicity

J JOHANNESSEN,L KELNER,D HANSELMAN,M SHIH,S MARKEY

Neurochemistry International（1985）

Cited 16|Views4
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Abstract
The compound 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produces a parkinsonian syndrome in humans and primates. We have previously found that metabolism of MPTP to a quaternary species is necessary for the expression of its neurotoxic effects. We now report that the metabolism of MPTP occurs in primate brain tissue in vitro, and present a model of MPTP neurotoxicity which incorporates our findings to date.
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