B-cell tolerance checkpoints in healthy humans and patients with systemic lupus erythematosus.
HUMAN IMMUNOLOGY: PATIENT-BASED RESEARCH(2005)
摘要
Antibodies are protective effector molecules in the body's immune defense against pathogens. However, if directed against the body's own tissues or organs, antibodies can also play a role in the pathogenesis of autoimmune disease. Here, we discuss our data on how autoreactive antibodies are regulated in healthy humans and how a failure to establish self-tolerance during early B-cell development in patients with systemic lupus erythematosus may predispose to the development of this autoimmune disease.
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关键词
B cell,tolerance,autoantibody,autoimmunity,SLE
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