TGF-β1/Smads通路与心肌梗死后心室重构的关系及辛伐他汀干预的影响
Medical Journal of West China(2011)
Abstract
目的:研究TGF-β1/Smads通路与心肌梗死后心室重构的关系及辛伐他汀(simvastatin,Sim)干预的影响.方法:清洁级Wistar大鼠40只随机分为4组,结扎大鼠冠状动脉建立-心肌梗死模型组(MI,n/=10)、假手术组(Sham,n=10)为对照组、辛伐他汀干预组(MI+Sim,n=10)和辛伐他汀自身对照组(Sim,n=10).8周后测量各组大鼠血液动力学、心室重量/体重、非梗死区胶原含量、荧光定量RT-PCR检测梗死区和非梗死区转化生长因子(TGF)β1mRNA、Smad3 mRNA、Smad7 mRNA的表达.结果:与假手术组和辛伐他汀干预组相比,MI组左室舒张末压、心室重量/体重、非梗死区胶原含量均增加,梗死区和非梗死区TGF-β1mRNA、Smad3 mRNA表达增加,而Smad7 mRNA表达降低(P<0.05).结论TGF-β1/Smads传导通路参与心肌梗死后的心室重构过程,Smad3对心室重构有促进作用,而Smad 7对心室重构有抑制作用.辛伐他汀可能通过押制Smad3表达,促进Smad7表达,从而有效改善心肌梗死后心室重构.
MoreTranslated text
Key words
Ventricular remodeling,Simvastatin,Transforming growth factor beta,Smad,Myocardial infarction
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined