Transpulmonary B-Type Natriuretic Peptide Uptake and Cyclic Guanosine Monophosphate Release in Heart Failure and Pulmonary Hypertension

Vojtech Melenovsky,Hikmet Al-Hiti,Ludmila Kazdova,Antonin Jabor,Petr Syrovatka,Ivan Malek,Jiri Kettner,Josef Kautzner

Journal of the American College of Cardiology（2009）

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摘要

Conclusions The H-PVR patients have stiffening of both pulmonary and systemic arteries, preserved transpulmonary BNP uptake, but diminished cGMP release, which is reversible by the administration of sildenafil. This study provides in vivo evidence that phosphodiesterase 5A inhibition restores sensitivity of pulmonary vasculature to endogenous cGMP-dependent vasodilators.

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heart failure,pulmonary vascular resistance,cGMP,sildenafil,pulmonary hypertension

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