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四乙酰葛根素在模拟人体胃肠环境中的稳定性研究

CHEN Guo-qing,ZHANG Yi,WENG Dai-qun,ZHOU Zhi,DU Hong-fei,HU Ren-yue,YANG Lu,YANG Da-jian

Lishizhen Medicine and Materia Medica Research（2010）

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Abstract
目的考察四乙酰葛根素(4ac)在模拟人胃肠环境的稳定性。方法采用高效液相色谱法测定4ac的降解剩余百分含量。结果 4ac在0.0625～1.0mg/ml浓度范围内线性良好,平均回收率为101.05%(RSD=1.59%)。人工肠液(加酶和不加酶)中,4ac在室温25℃和37℃时较稳定;人工胃液(加酶和不加酶)中,4ac在室温25℃和37℃时不稳定,半衰期分别为18.99,9.76,13.33h和8.22h。结论 4ac在人工肠液中稳定性较好,可开发肠溶制剂。
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Key words
HPLC,Tetraacetyl-puerarin,Artificial intestinal juice,Artificial gastric juice,Stability
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