Synthesis, binding and bioactivity of γ-methylene γ-lactam ecdysone receptor ligands: Advantages of QSAR models for flexible receptors

Bioorganic & Medicinal Chemistry(2010)

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摘要
Probing adaptable receptors: a new class of ligand for the ecdysone receptor demonstrates the utility of QSAR for investigating binding site shapes in conformationally plastic nuclear hormone receptors.
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关键词
Biological activity,Structure–activity relationships,Synthesis,Ecdysone receptor
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