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2,4-Diaminopyridine δ-opioid receptor agonists and their associated hERG pharmacology

Dafydd R. Owen,Margarita Rodriguez-Lens,Martin D. Corless,Steven M. Gaulier,Valerie A. Horne,Ross A. Kinloch,Graham N. Maw,David W. Pearce,Huw Rees,Tracy J. Ringer,Thomas Ryckmans,Blanda L.C. Stammen

Bioorganic & Medicinal Chemistry Letters（2009）

Cited 10|Views13
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Abstract
A δ-opioid agonist hit was converted into potent and selective analogues using library chemistry.
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Key words
2,4-Diaminopyridine,Delta opioid receptor,Agonist,Library chemistry,hERG
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