Diuretic Activity Of Aqueous Extract And Betulin From Colliguaja Integerrima In Rats

Five known compounds were isolated from the aerial parts of Colliguaja integerrima Gillies & Hook (Euphorbiaceae). A pharmacological evaluation of the diuretic activity of the plant was carried out in isotonic saline-loaded rats. The data reported in the present work indicate that the aqueous extract of the aerial parts from C integerrima showed a moderate diuretic activity. The urinary levels of sodium and potassium are increased by treatment with C integerima aqueous extract. This activity could be due, in part, to the presence of betulin isolated as the major metabolite of C integerrima.