The synthesis and antimicrobial evaluation of a new series of isoxazolinyl oxazolidinones
Bioorganic & Medicinal Chemistry Letters(2004)
摘要
A series of oxazolidinone antibacterial agents containing a 5-substituted isoxazol-3-yl moiety were synthesized via a nitrile oxide [3+2] dipolar cycloaddition reaction. These compounds were screened against a panel of susceptible and resistant Gram-positive organisms. Several analogs from this series were comparable to or more potent than linezolid in vitro.
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关键词
Antibacterial,Oxazolidinone,Resistant bacteria
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