A novel small molecule target in human airway smooth muscle for potential treatment of obstructive lung diseases: a staged high-throughput biophysical screening

Steven S An,Peter S Askovich,Thomas I Zarembinski,Kwangmi Ahn,John M Peltier,Moritz von Rechenberg,Sudhir Sahasrabudhe,Jeffrey J Fredberg

Respiratory research（2011）

引用 30|浏览15

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摘要

A newly identified mechanism of smooth muscle relaxation is the interaction between the small heat shock protein 20 (HSP20) and 14-3-3 proteins. Focusing upon this class of interactions, we describe here a novel drug target screening approach for treating airflow obstruction in asthma.

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关键词

Airway Smooth Muscle,Fluorescence Polarization,Airway Smooth Muscle Cell,Human Airway Smooth Muscle,Cell Stiffness

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