Role of b-Defensin-1 Polymorphisms in Mother-to-Child Transmission of HIV-1

Patients and Methods: Three hundred children, 118 HIV-1 infected and 182 HIV-1 uninfected, born to HIV-1–infected mothers who had not undergone antiretroviral therapy during pregnancy, and 84 HIV-1–infected mothers were analyzed. The single nucleotide polymorphisms -44C/G (rs1800972) and -52G/A (rs1799946) were genotyped by TaqMan allelic discrimination assay and sequencing. Statistical analyses were performed using SNPStats and Bonferroni correction for multiple tests.