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NO-NSAIDs: Gastric-sparing nitric oxide-releasable prodrugs of non-steroidal anti-inflammatory drugs

Kumar V.S. Nemmani,Sunil V. Mali,Namdev Borhade,Asif R. Pathan,Manoj Karwa,Venu Pamidiboina,S.P. Senthilkumar,Machhindra Gund,Arun K. Jain,Naveen K. Mangu,Nauzer P. Dubash,Dattatraya C. Desai,Somesh Sharma,Apparao Satyam

Bioorganic & Medicinal Chemistry Letters（2009）

Cited 45|Views6
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Abstract
Gastric-sparing NO-NSAIDs were designed, synthesized and evaluated. Among those evaluated, NO-Diclofenac (2b) has shown excellent bioavailability, anti-inflammatory activity, NO-releasing profile and gastric-sparing properties.
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Key words
NO-NSAIDs,Nitric oxide donors,Prodrugs of NSAIDs,Gastric-sparing NSAIDs,NO-Aspirin,NO-Diclofenac
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