独活寄生汤对荷瘤小鼠的抗肿瘤作用研究

Zhongguo shiyan fangjixue zazhi（2007）

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Abstract

目的:探讨独活寄生汤(DHJSHD)对小鼠肉瘤S180的抑制作用及其机制.方法:以S180荷瘤小鼠为模型,观察独活寄生汤对荷瘤鼠瘤重的影响和肿瘤组织病理学改变,用改良的MTT法测定荷瘤鼠主要免疫指标.结果:独活寄生汤能显著抑制S180瘤重,抑瘤率为32.45%～43.75%;肿瘤组织有明显的出血坏死及炎细胞浸润,同时独活寄生汤活化荷瘤鼠的T细胞增殖能力,促进其自然杀伤细胞(NK)活性和白介素-2(IL-2)分泌水平.结论:独活寄生汤能抑制小鼠肉瘤S180的生长,其机制可能与调节机体免疫功能有关.

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