Discovery of a highly orally bioavailable c-5-[6-(4-Methanesulfonyloxyphenyl)hexyl]-2-methyl-1,3-dioxane-r-2-carboxylic acid as a potent hypoglycemic and hypolipidemic agent.

Harikishore Pingali,Mukul Jain,Shailesh Shah,Sujay Basu,Pankaj Makadia,Amitgiri Goswami,Pandurang Zaware,Pravin Patil,Atul Godha,Suresh Giri,Ashish Goel,Megha Patel,Harilal Patel,Pankaj Patel

Bioorganic & Medicinal Chemistry Letters（2009）

引用 18|浏览9

暂无评分

摘要

A series of novel 1,3-dioxane-2-carboxylic acid derivatives have been reported as PPARα and γ agonists. Compound 13c exhibited potent hypoglycemic and lipid lowering activity and high oral bioavailability.

查看译文

关键词

Type 2 diabetes,PPAR agonist,1,3-Dioxane-2 carboxylic acid,Metabolic disorders

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要