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Dicarboxylic acid inhibitors of phospholipase A2

Dane M. Springer,Bing-Yu Luh,Stan V. D'Andrea,Joanne J. Bronson,Muzammil M. Mansuri,James R. Burke,Kurt R. Gregor,Paul L. Stanley,Kenneth M. Tramposch

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（1997）

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Abstract
Ten diacids were synthesized via a simple regio- and stereoselective aldol reaction. All of these compounds were good to excellent inhibitors of 14 kDa human platelet PLA(2), and many of these derivatives displayed activity in a phorbol-ester induced mouse ear edema assay. One of the new compounds reported here was selected for further development as a potential antipsoriasis agent. (C) 1997 Elsevier Science Ltd.
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phospholipase a2,dicarboxylic acid inhibitors
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