Synthesis and Characterization of Some Metal Complexes of 4,5-Diazafluoren-9-one and their Biological Effects on Human Carcinoma Cells

Guo-Liang Lu,Cheuk-Lam Ho,Qiwei Wang,Wai-Yeung Wong,Chung-Hin Chui,Raymond Siu-Ming Wong,Roberto Gambari,Fung-Yi Lau,Marcus Chun-Wah Yuen,Cindy Sze-Wai Tong,Andrew Kit-Wah Chan,Johnny Cheuk-On Tang,Kwok-Ping Ho,Gregory Yin-Ming Cheng

AUSTRALIAN JOURNAL OF CHEMISTRY（2009）

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摘要

Three new transition metal complexes of 4,5-diazafluoren-9-one, [(DAFO)PdCl2], [(DAFO)PtCl2], and [(DAFO)ZnCl2], were prepared in good yields by the reactions between appropriate metal chloride precursors and 4,5-diazafluoren-9-one under ambient conditions. The structures of these metal complexes were established by spectroscopic (Fourier-transform IR, NMR, and fast-atom bombardment mass spectrometry) techniques. The possible biological activity of these compounds on three human cancer cell lines including Hep3B, MDAMB-231, and SKHep-1 was investigated. The results obtained showed that both zinc- and platinum-containing compounds exhibit a similar growth inhibitory effect on these three cancer cell lines when compared with the prototypical cis-platin. In contrast, the corresponding palladium congener is virtually biologically inactive in these trials.

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关键词

biological chemistry,inorganic chemistry,organic chemistry,computational chemistry,biosensors,medicinal chemistry,photochemistry,physical chemistry,supramolecular chemistry,colloids,green chemistry,enzymes,electrochemistry,reaction mechanisms,catalysis,proteins,density functional theory,educational,surface chemistry,nanotechnology,analytical chemistry,crystal structures,sensors,ab initio calculations,peptide,quantum chemistry,macromolecules,biocatalysis,mass spectrometry,combinatorial chemistry,pharmaceutical chemistry,combinatorial,kinetics,ionic liquids,structure,interfaces,crystallography,spectroscopy,polymer chemistry,self assembly,amino acids

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