The discovery of novel indole-2-carboxamides as cannabinoid CB1 receptor antagonists

Phillip M. Cowley,James Baker,David R. Barn,Kirsteen I. Buchanan,Ian Carlyle,John K. Clark,Thomas R. Clarkson,Maureen Deehan,Darren Edwards,Richard R. Goodwin,David Jaap,Yasuko Kiyoi,Chris Mort,Ronald Palin,Alan Prosser,Glenn Walker,Nick Ward,Grant Wishart,Trevor Young

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（2011）

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摘要

The discovery and structure-activity relationship of a novel series of indole-2-carboxamide antagonists of the cannabinoid CB1 receptor is disclosed. Compound 26i was found to be a high potency, selective cannabinoid CB1 antagonist. (C) 2010 Elsevier Ltd. All rights reserved.

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Cannabinoid,CB1,Antagonist,Indole

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