CCR5 receptor antagonists: Discovery and SAR study of guanylhydrazone derivatives
Bioorganic & Medicinal Chemistry Letters(2007)
Abstract
High throughput screening (HTS) led to the identification of the guanylhydrazone of 2-(4-chlorobenzyloxy)-5-bromobenzaldehyde as a CCR5 receptor antagonist. Modifications of the guanylhydrazone resulted in the discovery of novel CCR5 antagonists.
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Key words
CCR5,Chemokine receptor antagonists
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