Discovery of novel (4-piperidinyl)-piperazines as potent and orally active acetyl-CoA carboxylase 1/2 non-selective inhibitors: F-Boc and triF-Boc groups are acid-stable bioisosteres for the Boc group.
Bioorganic & Medicinal Chemistry（2011）
Abstract
A series of (4-piperidinyl)-piperazine derivatives having a novel fluorine substituted tert-butoxycarbonyl (F-Boc) group was identified as potent ACC1/2 non-selective inhibitors.
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Key words
Acetyl-CoA carboxylase,Inhibitor,(4-Piperidinyl)-piperazine,tert-Butoxycarbonyl,F-Boc,Orally active
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