Peptide deformylase inhibitors with activity against respiratory tract pathogens

Stephen P East,R.Paul Beckett,Daniel C Brookings,John M Clements,Sheila Doel,Kenneth Keavey,Gilles Pain,Helen K Smith,Wayne Thomas,Alison J Thompson,Richard S Todd,Mark Whittaker

Bioorganic & Medicinal Chemistry Letters（2004）

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摘要

A series of analogues of the peptide deformylase (PDF) inhibitor BB-3497 where the P3′ amide bond was replaced with a ketone functionality is described. The in vitro antibacterial profiling of these compounds revealed that they demonstrate activity against pathogens associated with respiratory tract infections.

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关键词

Peptide deformylase,Inhibitors,Antibacterial

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