Cloning and characterization of a novel RNA-binding protein SRL300 with RS domains.

Y Sawada,Y Miura,K Umeki,T Tamaoki,K Fujinaga,S Ohtaki

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression（2000）

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摘要

AT-rich element binding factor 1 (ATBF1) mRNA encodes a transcription factor implicated in neuronal differentiation. A cDNA for the protein that can bind the 5′-noncoding sequence of the ATBF1 mRNA was cloned. The deduced protein, termed SRL300, contains a unique RNA-binding region, two large RS domains and many phosphorylation sites. SRL300 protein was detected in both human and rat cells.

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关键词

RNA-binding protein,cDNA cloning,RNA-binding region,RS motif

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