Effect of oxovanadium(IV) complexes on nondiabetic and streptozotocin-diabetic rats.

The effects of vanadium complexes with organic ligands, [VO(phen)2]SO4.3H2O, [VO(bpy)2]SO4.2H2O, and [VOCl2(Hmcp)2H2O], on blood glucose and plasma lipid levels were studied in nondiabetic and streptozotocin-diabetic rats and compared to that of [VO(mal)2] (the reference compound). The present results provide evidence that the compounds examined possess lower toxicity than [VO(mal)2]. One of the compounds examined, viz. [VO(bpy)2]SO4.2H2O, decreases, statistically significantly, the glucose level and a second one, viz. [VOCl2(Hmcp)2H2O], decreases, also significantly, the total cholesterol level.