Pharmacokinetics of Reverse Transcriptase Inhibitors
Infectious DiseaseReverse Transcriptase Inhibitors in HIV/AIDS Therapy(2006)
摘要
The nucleoside reverse transcriptase inhibitors (NRTIs) were the first class of compounds discovered to be potent inhibitors
of HIV replication (1 and, to date, these drugs remain the backbone of antiretroviral therapy. NRTIs are essentially prodrugs, inactive in their
parent form and requiring activation to exert their antiviral effects (2, 3).
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