Discovery of novel series of benzoic acid derivatives containing biphenyl ether moiety as potent and selective human β3-adrenergic receptor agonists: Part IV

Yutaka Nakajima,Masashi Imanishi,Shinji Itou,Hitoshi Hamashima,Yasuyo Tomishima,Kenichi Washizuka,Minoru Sakurai,Shigeo Matsui,Emiko Imamura,Koji Ueshima,Takao Yamamoto,Nobuhiro Yamamoto,Hirofumi Ishikawa,Keiko Nakano,Naoko Unami,Kaori Hamada,Kouji Hattori

Bioorganic & Medicinal Chemistry Letters（2008）

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摘要

SAR study of phenoxybenzoic acid derivatives as β3-AR agonist is described. Compounds 7g and 7k, exhibiting excellent β3-AR activity and selectivity, were discovered.

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关键词

β3-Adrenergic receptor agonist,Overactive bladder

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