Effects of cocaine on tyrosine hydroxylase activity in brain areas from SHR and WKY.

B Hoskins,S K Oh, Y T Tseng,R W Rockhold,I K Ho

BRAIN RESEARCH BULLETIN（1990）

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摘要

Basal tyrosine hydroxylase activity was the same in the nuclei accumbens and hypothalami of WKY and SHR. Basal striatal enzyme activity was lower in SHR than in WKY. Acute and subacute cocaine administration altered enzyme activity only in striata and nuclei accumbens of WKY. The central dopaminergic system of SHR appears to be less active and less sensitive to cocaine than that of WKY.

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tyrosine hydroxylase in brain,wistar-kyoto rats,cocaine,spontaneously hypertensive rats,tyrosine hydroxylase

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