Strategies for enhancing DNA vaccine potency by targeting antigen-presenting cells
Frontiers of Agriculture in China(2009)
Abstract
The potency of DNA vaccines to stimulate the immune response, especially the T-cell immune response against viral infections and tumors, depends mainly on the ability of antigen-presenting cells to process and present DNA-encoded antigens. Targeting the specific antigen to antigen-presenting cells is believed to be a crucial step for eliciting the T-cell response. Many strategies for enhancing DNA vaccine potency by targeting antigen-presenting cells have been developed. In this article, we generally introduce a T cell immune system and review some strategies which have been recently developed for enhancing DNA vaccine potency.
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Key words
DNA vaccine,antigen presenting cells,targeting,immune response
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