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双歧杆菌的脂磷壁酸激活巨噬细胞产生TNF-α的信号通路

Guo-zhen HUANG,Wei-bu CHEN,Li-mei LI,Xin-min HUANG

China Modern Medicine（2013）

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Abstract
目的 探讨双歧杆菌的脂磷壁酸对巨噬细胞产生肿瘤坏死因子α (TNF-α)的激活作用.方法 将7～10周龄的Bal/c小鼠20只随机均分成脂磷壁酸组和对照组,脂磷壁酸组小鼠给予注射脂磷壁酸溶液3ml,每天1次,连续10d;对照组小鼠给予注射缓冲溶液3ml,每天1次,连续10 d.观察两组小鼠TNF-α活性.结果 脂磷壁酸组小鼠的TNF-α为(78.45±34.21)U/ml,对照组小鼠的TNF-α为(34.54±13.45) U/ml,差异有统计学意义(P＜0.05).结论 双歧杆菌的脂磷壁酸能激活巨噬细胞产生TNF-α,从而为临床治疗提供依据.
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Key words
Macrophages,Lipoteichoic acid,Tumor necrosis factor α
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